A study published in Scientific Reports suggests that a hormone treatment combining estriol and progesterone may help ease cognitive symptoms such as memory lapses and trouble concentrating in menopausal women. ^[1] A study published in Scientific Reports in 2026 by UCLA Health evaluated a combined therapy of estriol and progesterone on a small group of 20 menopausal women with an average age of 53. ^[2] After the 12-month treatment regimen, participants reported significant reductions in brain fog and problems with concentration, working memory, processing speed, verbal memory, and problem-solving. ^[3] Dr. Rhonda Voskuhl, a neurologist and senior author of the study at UCLA Health, stated that there is currently no FDA-approved treatment type or dose that specifically targets cognitive symptoms during menopause. ^[4] The study was an observational case series that followed 20 menopausal women with an average age of 53 over a 12-month period. ^[5] Experiments on middle-aged mice showed that estriol reduced markers of pathology in the hippocampus and improved performance in working memory and spatial tasks. ^[6] Researchers declared that confirmation in larger, placebo-controlled clinical trials using standardized brain imaging and cognitive tests is necessary before considering changes in clinical practice. ^[7]