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Tuesday, September 1, 2026 · UTC
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PRAGUE-26 trial: Catheter-directed thrombolysis cuts pulmonary embolism complications

PRAGUE-26 trial found catheter-directed thrombolysis reduced the primary endpoint from 6.8% to 0.7% versus anticoagulation alone in intermediate-high-risk pulmonary embolism.

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According to results presented at ESC Congress 2026, the primary endpoint-a composite of all-cause mortality, pulmonary embolism recurrence, or cardiorespiratory decompensation/collapse within seven days-occurred in 0.7% of patients receiving catheter-directed thrombolysis versus 6.8% receiving standard anticoagulation alone (relative risk 0.10, 95% CI 0.02-0.44, p<0.001). [1] Scientists from the Department of Organic Chemistry at the Faculty of Science, Charles University, Prague, reported a new method for synthesizing complex molecules in the journal Organic Letters. [2] The PRAGUE-26 study, led by Viktor Kočka and Josef Kroupa from Charles University and University Hospital Kralovske Vinohrady in Prague, Czechia, randomized 558 patients with intermediate-high-risk pulmonary embolism at 11 Czech sites to receive either catheter-directed thrombolysis or standard anticoagulation therapy alone. [3] The study reported no significant difference in bleeding events within seven days between the catheter-directed thrombolysis group (4.6%) and the standard-care group (5.0%, p=0.846). [4] A team led by Eliška Matoušová designed and tested an elegant three-step process that significantly reduces problems associated with previous synthesis methods. [5] Galiellalactone, a compound isolated from the fungus Galiella rufa, affects the signaling protein STAT3 and is being studied for treating chemotherapy-resistant prostate cancer. [6] The new method simplifies the preparation of complex molecules related to natural compounds known for anticancer and anti-inflammatory effects. [7] The Czech Crown Jewels will be exhibited in the Vladislav Hall of Prague Castle from September 19 to 28, 2026, commemorating 500 years since Ferdinand I Habsburg ascended the throne. [8] The National Heritage Institute (NPÚ) will open selected state castles, palaces, and monasteries across the Czech Republic for free on Sunday, September 27, 2026, requiring advance online reservations. [9] The Prague 10 Science Festival will take place on Saturday, September 12, 2026, at Gutovka with 25 stations featuring chemistry experiments, LEGO robotics, and nature activities. [10] Universities and research institutes, including the Czech Technical University and Charles University, will open their doors to the public on Friday, September 25, 2026, for free science shows and lectures. [11]
What this stands on
  1. According to results presented at ESC Congress 2026, the primary endpoint-a composite of all-cause mortality, pulmonary embolism recurrence, or cardiorespiratory decompensation/collapse within seven days-occurred in 0.7% of patients receiving catheter-directed thrombolysis versus 6.8% receiving standard anticoagulation alone (relative risk 0.10, 95% CI 0.02-0.44, p<0.001). · Medical Xpress
  2. Scientists from the Department of Organic Chemistry at the Faculty of Science, Charles University, Prague, reported a new method for synthesizing complex molecules in the journal Organic Letters. · Phys.org
  3. The PRAGUE-26 study, led by Viktor Kočka and Josef Kroupa from Charles University and University Hospital Kralovske Vinohrady in Prague, Czechia, randomized 558 patients with intermediate-high-risk pulmonary embolism at 11 Czech sites to receive either catheter-directed thrombolysis or standard anticoagulation therapy alone. · Medical Xpress
  4. The study reported no significant difference in bleeding events within seven days between the catheter-directed thrombolysis group (4.6%) and the standard-care group (5.0%, p=0.846). · Medical Xpress
  5. A team led by Eliška Matoušová designed and tested an elegant three-step process that significantly reduces problems associated with previous synthesis methods. · Phys.org
  6. Galiellalactone, a compound isolated from the fungus Galiella rufa, affects the signaling protein STAT3 and is being studied for treating chemotherapy-resistant prostate cancer. · Phys.org
  7. The new method simplifies the preparation of complex molecules related to natural compounds known for anticancer and anti-inflammatory effects. · Phys.org
  8. The Czech Crown Jewels will be exhibited in the Vladislav Hall of Prague Castle from September 19 to 28, 2026, commemorating 500 years since Ferdinand I Habsburg ascended the throne. · Blesk.cz
  9. The National Heritage Institute (NPÚ) will open selected state castles, palaces, and monasteries across the Czech Republic for free on Sunday, September 27, 2026, requiring advance online reservations. · Blesk.cz
  10. The Prague 10 Science Festival will take place on Saturday, September 12, 2026, at Gutovka with 25 stations featuring chemistry experiments, LEGO robotics, and nature activities. · Blesk.cz
  11. Universities and research institutes, including the Czech Technical University and Charles University, will open their doors to the public on Friday, September 25, 2026, for free science shows and lectures. · Blesk.cz
We could not place any of them by their address. None is an official body: that part stands on reporting, not on the underlying document or transcript.
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