{ "story_id": "69c7881ac74655a9bbfe3ea0aa28806d", "desk": "drm3", "revision": 1, "published_at": "2026-09-01T16:07:00.000Z", "content_hash": "357b80667338ddbb74913de4697480e44f7c95c0718f079c8d0050b66d1bac68", "hash_basis": "sha256 over `headline\\ndek\\nprose`, plus `\\n` + the canonical citations JSON when any source is placed, plus `\\n#blog` for blogs", "basis": { "headline": "PRAGUE-26 trial: Catheter-directed thrombolysis cuts pulmonary embolism complications", "dek": "PRAGUE-26 trial found catheter-directed thrombolysis reduced the primary endpoint from 6.8% to 0.7% versus anticoagulation alone in intermediate-high-risk pulmonary embolism.", "prose": "According to results presented at ESC Congress 2026, the primary endpoint-a composite of all-cause mortality, pulmonary embolism recurrence, or cardiorespiratory decompensation/collapse within seven days-occurred in 0.7% of patients receiving catheter-directed thrombolysis versus 6.8% receiving standard anticoagulation alone (relative risk 0.10, 95% CI 0.02-0.44, p<0.001). [^1]\n\nScientists from the Department of Organic Chemistry at the Faculty of Science, Charles University, Prague, reported a new method for synthesizing complex molecules in the journal Organic Letters. [^2]\n\nThe PRAGUE-26 study, led by Viktor Kočka and Josef Kroupa from Charles University and University Hospital Kralovske Vinohrady in Prague, Czechia, randomized 558 patients with intermediate-high-risk pulmonary embolism at 11 Czech sites to receive either catheter-directed thrombolysis or standard anticoagulation therapy alone. [^3]\n\nThe study reported no significant difference in bleeding events within seven days between the catheter-directed thrombolysis group (4.6%) and the standard-care group (5.0%, p=0.846). [^4]\n\nA team led by Eliška Matoušová designed and tested an elegant three-step process that significantly reduces problems associated with previous synthesis methods. [^5]\n\nGaliellalactone, a compound isolated from the fungus Galiella rufa, affects the signaling protein STAT3 and is being studied for treating chemotherapy-resistant prostate cancer. [^6]\n\nThe new method simplifies the preparation of complex molecules related to natural compounds known for anticancer and anti-inflammatory effects. [^7]\n\nThe Czech Crown Jewels will be exhibited in the Vladislav Hall of Prague Castle from September 19 to 28, 2026, commemorating 500 years since Ferdinand I Habsburg ascended the throne. [^8]\n\nThe National Heritage Institute (NPÚ) will open selected state castles, palaces, and monasteries across the Czech Republic for free on Sunday, September 27, 2026, requiring advance online reservations. [^9]\n\nThe Prague 10 Science Festival will take place on Saturday, September 12, 2026, at Gutovka with 25 stations featuring chemistry experiments, LEGO robotics, and nature activities. [^10]\n\nUniversities and research institutes, including the Czech Technical University and Charles University, will open their doors to the public on Friday, September 25, 2026, for free science shows and lectures. [^11]", "cited": "[{\"statement\":\"According to results presented at ESC Congress 2026, the primary endpoint-a composite of all-cause mortality, pulmonary embolism recurrence, or cardiorespiratory decompensation/collapse within seven days-occurred in 0.7% of patients receiving catheter-directed thrombolysis versus 6.8% receiving standard anticoagulation alone (relative risk 0.10, 95% CI 0.02-0.44, p<0.001).\",\"source\":\"Medical Xpress\",\"instrument\":\"News\",\"claim_key\":null,\"published_at\":\"2026-09-01T01:00:01.000Z\",\"publisher_count\":1,\"sources\":[\"Medical Xpress\"]},{\"statement\":\"Scientists from the Department of Organic Chemistry at the Faculty of Science, Charles University, Prague, reported a new method for synthesizing complex molecules in the journal Organic Letters.\",\"source\":\"Phys.org\",\"instrument\":\"News\",\"claim_key\":null,\"published_at\":\"2026-08-31T14:40:15.000Z\",\"publisher_count\":1,\"sources\":[\"Phys.org\"]},{\"statement\":\"The PRAGUE-26 study, led by Viktor Kočka and Josef Kroupa from Charles University and University Hospital Kralovske Vinohrady in Prague, Czechia, randomized 558 patients with intermediate-high-risk pulmonary embolism at 11 Czech sites to receive either catheter-directed thrombolysis or standard anticoagulation therapy alone.\",\"source\":\"Medical Xpress\",\"instrument\":\"News\",\"claim_key\":null,\"published_at\":\"2026-09-01T01:00:01.000Z\",\"publisher_count\":1,\"sources\":[\"Medical Xpress\"]},{\"statement\":\"The study reported no significant difference in bleeding events within seven days between the catheter-directed thrombolysis group (4.6%) and the standard-care group (5.0%, p=0.846).\",\"source\":\"Medical Xpress\",\"instrument\":\"News\",\"claim_key\":null,\"published_at\":\"2026-09-01T01:00:01.000Z\",\"publisher_count\":1,\"sources\":[\"Medical Xpress\"]},{\"statement\":\"A team led by Eliška Matoušová designed and tested an elegant three-step process that significantly reduces problems 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