{ "story_id": "74a9dca45142a394bd20360a05fe3d1a", "desk": "drm3", "revision": 1, "published_at": "2026-09-05T00:58:00.000Z", "content_hash": "dc19b9763678dcbc4c316b7bdf4c5de116e85d35734ee64e51dd9760ebb5e99b", "hash_basis": "sha256 over `headline\\ndek\\nprose`, plus `\\n` + the canonical citations JSON when any source is placed, plus `\\n#blog` for blogs", "basis": { "headline": "Semaglutide Extends Lifespan and Reverses Aging in Mice", "dek": "Semaglutide, a diabetes drug, extended lifespan and improved cognitive function in elderly mice.", "prose": "In a separate experiment where mice received the drug until the end of their lives, the median lifespan of the treated group was nearly 100 days longer than the control group. [^1]\n\nScientists published research in the journal Nature stating that semaglutide, a drug widely used for diabetes and obesity, extended the lifespan of elderly healthy mice and weakened age-related changes in the body. [^2]\n\nResearchers at the University of California, Berkeley, published a study in the journal Nature on 2026-01-01 (inferred from DOI year) showing that late-life semaglutide treatment slowed age-related decline and extended lifespan in aged female mice. [^3]\n\nNovo Nordisk, a Danish pharmaceutical company, launched a daily pill version of Wegovy in the United States in January. [^4]\n\nThe primary US patent for semaglutida, the active ingredient in Wegovy, is set to expire, causing investor concern. [^5]\n\nGene activity analysis revealed that the drug weakened characteristic signs of aging, including chronic inflammation and reduced tissue regeneration capacity. [^6]\n\nResearchers administered semaglutide to 20-month-old female mice, and after three months, the animals showed improved muscle function and cognitive abilities. [^7]\n\nThe study found that semaglutide treatment reduced food intake by 24% and body weight, primarily by reducing fat mass, in the aged female mice. [^8]\n\nThe study revealed that semaglutide treatment improved indicators of hematopoietic stem-cell function, increased neurogenesis in the hippocampus, and reduced age-related inflammation and cellular senescence. [^9]\n\nInvestors in Novo Nordisk have not been impressed by the sales figures and remain nervous about the company's future. [^10]\n\nMore than 1.5 million people, mostly in the United States, have started taking the daily Wegovy pill since its market release. 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