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    "headline": "Cambridge scientists identify ISM2 protein as predictor for preeclampsia and fetal growth restriction",
    "dek": "Low early-pregnancy levels of placental protein ISM2 predict preeclampsia and fetal growth restriction, Cambridge study finds",
    "prose": "Researchers at the University of Cambridge identified the protein isthmin-2 (ISM2) as a predictor for preeclampsia and fetal growth restriction, based on a study published in Nature Medicine in 2026. [^1]\n\nPreeclampsia affects up to one in 14 pregnant women globally and can lead to stillbirth or maternal death by reducing blood flow through the placenta. [^2]\n\nFetal growth restriction affects roughly 3% to 10% of pregnancies in high-income countries and up to one in five pregnancies globally. [^3]\n\nLow circulating levels of ISM2 around three months into pregnancy were the strongest indicator that a pregnancy would develop preeclampsia or fetal growth restriction. [^4]\n\nProfessor Gordon Smith, head of the Department of Obstetrics and Gynecology at the University of Cambridge, said early-pregnancy maternal levels of isthmin-2 are much better at predicting complications than existing tests and could enable better identification of at-risk pregnancies, as well as potential treatments such as stimulating ISM2 production in the placenta. [^5]\n\nDr. Gordon Smith, study leader and head of Cambridge's Department of Obstetrics and Gynaecology, stated that low circulating levels of the protein isthmin-2 (ISM2) about three months into pregnancy were the strongest indicator of future preeclampsia or fetal growth restriction. [^6]\n\nFetal growth restriction affects up to 10% of pregnancies in high-income countries and up to one in five pregnancies globally, making it a leading cause of complications in newborns. [^7]",
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