According to a joint statement led by the Mexican Online Sales Association (AMVO), between 15% and 30% of sellers active during 2025 stopped posting products on digital platforms during the first quarter of 2026. ^[1] Mexican business organizations warned that 8% VAT and 2.5% ISR tax retentions applicable to online sales since January 2026 are affecting the liquidity of Micro, Small, and Medium Enterprises (Mipymes) in Mexico. ^[2] A study by RX Mexico and Euromonitor places over-the-counter medications as the largest segment in retail with sales of $2,968 million. ^[3] According to the Mexican Online Sales Association (AMVO), between 34% and 49% of consumers intend to acquire health, pharmacy, and beauty products through digital channels. ^[4] Mexican consumers are increasingly purchasing vitamins, supplements, and personal care products from pharmacies via their mobile devices. ^[5] Data presented by organizations indicates that income for sellers who remained active dropped by between 20% and 52% compared to the previous year. ^[6] The 77% of sellers consulted perceive an impact on their liquidity, while 68% consider their capacity to reinvest in inventory, personnel, or growth has been reduced. ^[7] According to the Mexican Online Sales Association (AMVO), 62% of buyers acquire physical products at least once a month. ^[8]